Run is the twenty-second episode of the second season of Designated Survivor and the forty-third episode overall. It aired on May 16, 2018.
A natural disaster endangers two White House staffers while President Kirkman makes an announcement no one saw coming, as well as dealing with turmoil from the hacker and congressional investigation.
- Kiefer Sutherland as Tom Kirkman
- Paulo Costanzo as Lyor Boone
- Adan Canto as Aaron Shore
- Italia Ricci as Emily Rhodes
- LaMonica Garrett as Mike Ritter
- Zoe McLellan as Kendra Daynes
- Kal Penn as Seth Wright
- Maggie Q as Hannah Wells